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PLC-2 then competes with PI-3K for PIP 2 which it hydrolyzes into IP 3 (inositol 1,4,5-trisphosphate), which ultimately raises intercellular calcium, and diacylglycerol (DAG), which activates portions of the PKC family

Lee JK, Kim TS, Kim DW, Han SH
doi: 10.3748/wjg.v17.i39.4414
Despite the fact that both groups had similar food intake and ambulatory exercise, COMBI therapy significantly reduced body weight increase induced by HFD, fat mass growth, and hepatic steatosis (Salic et al., 2019)