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Moreover, plain radiographs were used to determine the grade of intervertebral disc degeneration in the present study, impeding the assessment of facet joint degeneration and potentially limiting the comparability with in vivo studies using magnetic resonance imaging, as gradings of disc degeneration from X-rays and magnetic resonance images were found to differently predict the flexibility of the lumbar spine 43

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Elimination occurs primarily through renal excretion of metabolites, with the peptide and its fragments detectable in urine for up to 4 days following administration despite plasma clearance within hours