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In fact, the very first drug approved for the treatment of AUD was disulfiram, a drug that inhibits ALDH2 and, therefore, capitalizes on the resultant aversive effects of acetaldehyde accumulation after alcohol intake (308)
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Preclinical studies indicate that NNMT knockdown or inhibition can protect against diet-induced weight gain and improve metabolic parameters without reducing food intake [5] [6]
It's important to investigate the cause of deficiency with tests such as anti-intrinsic factor antibodies and to check folate status
