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Patients with inherently low dopaminergic function are particularly predisposed to hyperalgesia and reduced pain tolerance

Conversely, HFD-fed mice showed a marked reduction in GSH concentration without treatment, but coffee brew treatment in HFD-fed mice ameliorated GSH reduction (Fig

Clinical application considerations include the potential for plant antioxidants as adjunctive therapy alongside conventional PDE5 inhibitors

notably, patient compliance with the treatment regimen exceeded our expectations

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