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We also demonstrate the utility of HRMS discovery-based approach (sometimes referred to as pharmacometabolomics in clinical applications ( 35, 36 )) to advance a step forward towards precision and personalized medicine and uncover new metabolites markers that can be used to provide better typing of patients related to the kinetic of elimination of a drug or to identify inter-individual susceptibility to develop drug-induced liver injury, as it is the case here with APAP

Safe S, Jayaraman A, Chapkin RS et al (2021) Flavonoids: structurefunction and mechanisms of action and opportunities for drug development

PloS one 7 (11), e49275

As absorption is reduced, body stores become low and a deficiency occurs Underlying diseases most commonly include: IBD (inflammatory bowel disease) Intestinal cancer (especially small cell lymphoma) Liver disease Pancreatitis and other pancreatic diseases Symptoms of low B12 levels Typically found in middle-aged or older cats that present with: Weight loss Diarrhea Vomiting Anorexia Thickened intestines In humans, B12 deficiency may also be associated with dementia, cardiovascular disease, and a certain type of anemia, although these are not specifically recognized problems in cats