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View on PubMed Involvement of the AT1 Receptor in Effects of Angiotensin IV and LVV-Haemorphin 7 on Hippocampal Memory Demonstrated that angiotensin IV analogs (the parent class of Dihexa) improve hippocampal memory performance in rodents, supporting the AT4/IRAP receptor pathway as a target for cognitive enhancement (J Neurochem, 2010)

Animal models further demonstrate changes in adipose tissue signaling consistent with increased fatty acid mobilization and oxidation