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In a crossover study conducted in healthy male and female volunteers, high cumulative doses of Albuterol Sulfate HFA Inhalation Aerosol (1,080 mcg of albuterol base administered over one hour) yielded mean peak plasma concentrations (C max ) and systemic exposure (AUC inf ) of approximately 4,100 pg/mL and 28,426 pg/mLhr, respectively compared to approximately 3,900 pg/mL and 28,395 pg/mLhr, respectively following the same dose of an active HFA-134a albuterol inhaler comparator

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Protein modification products Proteins including enzymes, may be damaged by OS, leading to conformational modifications that result in a loss or impairment of enzymatic activity [Davies, 2016]
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