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Toxicology studies have shown no lethal dose (LD1) could be achieved in animal models, suggesting a wide therapeutic window

In expressing their own periodicity they drift away from normal clock time such that intermittently they will be in night phase during the day (e.g., secretion of melatonin, low alertness and performance) and day phase during the night (low melatonin, poor sleep)

[DOI] [PMC free article] [PubMed] [Google Scholar] Benovic JL, Khn H, Weyand I, Codina J, Caron MG, Lefkowitz RJ