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Because L-DOPA may increase the oxidative stress causing dopaminergic neuron loss in PD, and since bilirubin is a well-known antioxidant, an increased bilirubin level has been interpreted as a possible protective response to the disease [48]

Although its expression levels vary on the tissue type, neurofibromin is ubiquitously expressed in multiple tissues, especially in the neurons and astrocytes of the central nervous system (CNS), as well as Schwann cells in the peripheral nervous system (PNS) [261,262], where the protein controls growth, survival, proliferation and differentiation of cells mainly via two intracellular pathways

From first patient to the SELECT cardiovascular outcomes trial: another 15 years
