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[4] The second activation step takes place predominantly in the kidneys where 1-hydroxylase converts 25-hydroxyvitamin D to 1,25-dihydroxyvitamin D (calcitriol), an active secosteroid hormone that binds nuclear receptors in enterocytes, osteoblasts, renal tubules, parathyroid cells, and numerous immune and endocrine cells to modulate hundreds of genes involved in calcium-phosphate homeostasis, skeletal remodelling, and immunoregulation

& Liu, J

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The combination of tirzepatide and AOD9604 is being explored in some research settings, since tirzepatide (a GLP-1/GIP receptor agonist) works through different mechanisms including appetite suppression and improved insulin sensitivity

Cost-Effectiveness and Accessibility: A Practical Consideration Injections typically incur higher costs due to doctor visits and administration fees, while oral pills provide a more affordable and accessible option