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Huberman stresses the importance of satisfying foundational health needs with broad-spectrum supplements (like multivitamins) before experimenting with single-ingredient formulations that can augment specific aspects of health, like sleep, hormone support, and cognitive function

The transcription of a set of genes related to the regulation of heme synthesis and transformation, such as heme oxygenase 1 (HO-1), ferrochelatase (FECH) and SLC48A1, is upregulated by NRF2 [100,101,102,103]

These foods are rich in selenium: Baked beans Beef Brazil nuts Brown rice Chicken Cottage cheese Eggs Fish Ham Organ meats Pork Sunflower seeds Turkey Supplement with N-acetylcysteine N-acetylcysteine (NAC): NAC is a precursor to cysteine, a key glutathione component

The tight junctions transmembrane proteins claudins, tricellulin, and occludin restrict paracellular diffusion of water-soluble substances from blood to the brain (Hawkins and Davis, 2005)

Dihexa can often be safely combined with other cognitive enhancement therapies including omega-3 fatty acids, B-vitamins, nootropic supplements like Lions Mane or Bacopa monnieri, acetylcholine precursors, and brain-supporting nutrients when properly coordinated under medical supervision