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Nutrient competition in the TME, coupled with conditions like acidosis and hypoxia, can trigger ferroptosis, which in turn contributes to cancer progression (Fig

In addition, it was shown that the administration of NAC may have reduced oxidative stress activity and caused the stabilisation of homocysteine levels

Additionally, emodin is synthesized as a secondary metabolite by molds and lichens [431, 432]

The G-protein beta and gamma subunits (G) subunits downstream of G-protein-coupled receptors (GPCRs), also trigger activation of p110

These findings support humanized PDX models as a platform for functionally interrogating tumour-intrinsic drivers of immune composition and immune evasion in solid tumours
