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malondialdehyde) in dopamine-rich striatum and also in (dopamine-poor) frontal cortex (26), and a trend for lower GSH in a MA subgroup that experienced severe dopamine loss (27)

Starting at the lower end of this range and gradually increasing allows you to assess tolerance and response

Between 10 30% of the population have a mutation in the MTHFR gene and it is becoming increasingly clear that this could have pronounced medical implications

Conclusions Although preclinical models reflecting CIPN have provided a deeper insight into mechanisms that initiate and maintain antitumor drug-induced neurotoxicity, this clinical entity currently cannot be prevented