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Nevertheless, the homozygote mutant genotype leads to hyperhomocysteinemia only when plasma folate status is low in healthy subjects and in patients with cardiovascular disease, thus subjects with this MTHFR mutation may be sensitive to low folate intake (Christensen et al, 1997

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But on top of supporting energy, getting enough B12 is required for the production and maintenance of healthy red blood cells, supporting proper neurological function, and maintaining a healthy nervous system