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Keith B, Johnson RS, Simon MC

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First discovered in 1905, L-Carnitine serves as an essential cofactor in cellular energy metabolism, with approximately 95% of the body's carnitine stores located in skeletal muscle and cardiac tissue

KEY POINTS TO REMEMBER Treatment of lipid disorders should be initiated in childhood, since delaying therapy to adulthood may lead to development of cardiovascular diseases as early at a young age

In contrast, in HEK-293T cells exposed to the same conditions, HSPA5 mRNA levels did not increase, whereas XBP1s expression was elevated in an HSF1-dependent manner