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Among the antioxidants shown to be protective in animal models of influenza are the xanthine oxidase inhibitor allopurinol, 54 quercetin, 58 superoxide dismutase, 59 thioredoxin, 60 NAC (alone 61 or with ribavirin 62 or oseltamavir 63 ), and GSH itself

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In the chronic toxicity experiment, L-NAME caused severe tissue damage (myocardial and hepatic cell necrosis, necrosis of the lymphoid cells in the spleen) while L-arginine provoked predominantly congestion, edema and hemorrhages in all organs