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Biosynthesis of ergothioneine and hercynine by mycobacteria

The authors note consistently positive healing signal across studies but explicitly flag that the bulk of the work has been done in small-rodent models useful for calibrating any extrapolation to larger-animal or human work and for grounding any soft-tissue-research literature review

(PubMed) Aggarwal ML, Chacko KM, Kuruvilla BT

[DOI] [PubMed] [Google Scholar] 140.Shimbashi W, Sugitani I, Kawabata K, Mitani H, Toda K, et al

Clinical data from LS patients also highlight marked gliosis as a characteristic finding, potentially resulting from reactive processes secondary to neuronal damage but it could be also a result of an increased propensity of NPCs to differentiate into astrocytes due to LS-causative mutations and mitochondrial dysregulation