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Description
Urology 65 , 400405 (2005)
IRB2020-WZ-119
10.1002/bip.21328 32 DetienneS.WelsbyI.CollignonC.WoutersS.CocciaM.DelhayeS.et al (2016)
Targeting Autophagy in Cancer
Its cytotoxic mode of action is mediated by its interaction with DNA to form DNA adducts, primarily intrastrand crosslink adducts, which activate several signal transduction pathways, including those involving ATR, p53, p73, and MAPK, and culminate in the activation of apoptosis
