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The reaction proceeds via nucleophilic attack of the -amino group on the side-chain amide to form a -lactam with the elimination of ammonia from the side-chain

This could easily turn into a somewhat off-topic discussion around whether consuming animal products is necessary to acquire sufficient quantities of dietary B12 for us humanseven though that is the very basis of, and the reason such an argument around cattle being regularly fed B12 supplements exists

Summary: Vitamin B12 supplements can occasionally cause mild stomach side effects including nausea, diarrhoea, abdominal cramping, and indigestion, though these are generally uncommon and temporary

DSIP offers more targeted effects on specific sleep and stress pathways

This might include increasing the number of neurotransmitter receptors