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Considering nicotine use disorder (NUD), there are several data supporting beneficial effects of acute or chronic NAC treatment on nicotine reward assessed in self-administration or conditioned place preference rodent models [27, 35,36,37] (Table 1)

In a rat model, melatonin demonstrated inhibition of NMDA receptor activation and subsequent NMDA receptor-mediated Ca 2+ entry into striatal neurons, suggesting a potential protective role [79]

elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

Bellono, N

This imbalance causes overactivity of the indirect pathway and a reduction in the activity of the direct pathway, leading to typical motor symptoms such as tremors, rigidity, and bradykinesia