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Cytokines, such as TNF and IL-6, and their corresponding receptors and receptor oligomerization, facilitate JAK phosphorylation and activation upon receptor binding, thereby mediating STAT phosphorylation

However, research is mixed

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These secretagogues are distinct from the growth hormone-releasing (GHR) or Growth Hormone Releasing Peptide (GHRP) in that they share no sequence relation and derive their function through action at a completely different receptor, the ghrelin receptor