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vascular endothelial growth factor (VEGF) and angiopoietin-1, leading to the induction of genes involved in angiogenesis and thus represent therapeutic targets for the inhibition of tumor angiogenesis [122]
An analog of taurocholic acid, tauroursodeoxycholic acid (TUDCA), is a naturally occurring bile acid and is a conjugate of taurine and ursodeoxycholic acid (UDCA)
doi: 10.1007/s10549-020-05575-9 [DOI] [PMC free article] [PubMed] [Google Scholar] 250
In the phase II study, the MET positive subgroup of patients, as determined by IHC, had a prolonged mOS in the rilotumumab arm compared to the placebo arm [86]
and Qureshi, W
