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A membrane-selectivity of DEFA1 for negatively charged membranes was examined using liposomes composed of defined phospholipids

This provides the possibility of a glutathione (G-SH) substitution for the intracellular space, without an endogenous glutathione biosynthesis which is still possible depending on the degree of cell damage being inhibited or blocked by means of competitive and / or allosteric inhibition

Cortisol, a glucocorticoid hormone, is known to have neurotoxic effects when present in excess

Unlike B12 deficiency, which produces recognisable neurological and haematological symptoms, excess vitamin B12 typically remains asymptomatic and is discovered incidentally during routine blood tests

Arch Gen Psychiatry 2011