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Vitamin D receptors are present in tissues such as the pancreas, liver, adipose tissue, and skeletal muscles, which help maintain energy balance

In addition, periodontal pathogens have vast adaptive plasticity when under stress in their habitat, another complicating factor

Therefore, it is relevant to evaluate if lysosomal alterations contribute to the development of cardiovascular diseases in the context of DS

Using mouse models, Withaar et al

Gastroenterology: 2009
