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DCA has been described as an allosteric PDK inhibitor that, at mM concentration (IC50) and in concomitance with ADP, binds to the pyruvate pocket of the PDK complex enzyme, avoiding attachment of the kinase domain to the E2 domain 55,56

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(2000) observed a decrease in the serum cobalamin concentration (in the normal range) in cats with cardiomyopathy and thromboembolism compared to healthy cats

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