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Antibiotic therapy may reduce middle ear damage in some patients with acute OM (Venekamp et al) but in 60% of cases, the infection spontaneously clears without antibiotic intervention and without complications (Venekamp et al]
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Takashima A, Honda T, Yasutake K, Michel G, Murayama O, Murayama M, Ishiguro K, Yamaguchi H: Activation of tau protein kinase I/glycogen synthase kinase-3beta by amyloid beta peptide (2535) enhances phosphorylation of tau in hippocampal neurons

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