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The dimer form of 6-thio-dG shows strong potential to enhance chemotherapeutic efficacy by effectively inhibiting GSTP1 and overcoming drug resistance

We first assessed the impact of giredestrant and a sub-saturating (200 nM) concentration of palbociclib, intended to model the clinical scenario, as single agents and in combination, on the lipid profile of both MCF-7 and T47D cells 7 days after treatment