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This method relies on analysis of abundance covariation between proteins in a genetically defined diversity outbred mouse model (DO mice) that parallels the genetic and phenotypic variability found in humans 11

Bacterial strains The indicator pathogenic bacteria used in this study were purchased from American-type culture collection (ATCC)

For single sgRNA cloning, the oligonucleotides containing 20 bp protospacer and overhang were obtained from Integrated DNA Technologies and cloned into the Bsm BI-v2 (New England Biolabs, catalogue no

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