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TMAO is an independent risk factor of cardiovascular morbidity and mortality in patients with established IHD or CKD 18,19 with accumulating evidence suggesting direct causal effects 47

Ursini F, Heim S, Kiess M, et al

Compounds such as MK-0493 and MC4-NN2-0453, which do not activate MC4R as potently as other agonists, demonstrated no weight loss in humans despite dosing for 126 and 70 days, respectively ( Current melanocortin agonists are addressing some of the issues encountered by previous failed agonists

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