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Whilst traditionally thought to be absorbed directly through oral mucous membranes, research indicates that much of the dose is swallowed and absorbed via the digestive system, similar to standard oral tablets

To achieve blood levels of at least 30 ng/mL, adults living at temperate latitudes (think: anywhere with distinct seasons) need 800 to 1,000 IU per day, ideally from vitamin D3, which is more effective than D2

Due to the limited intraoperative resection scope of the ligamentum flavum, it can play a barrier role, reduce the possibility of drugs entering the dural sac, and improve safety