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Tryptophan hydroxylase 2 (TPH2), highly expressed in the cortex, is a rate-limiting enzyme that mediates serotonin synthesis from tryptophan (Park, 2013).The mutation of TPH2 has been found to be a risk factor for genetic predisposition to ADHD in children (Abo El Fotoh, 2020, Brookes, 2006)

Gut microbiota dysbiosis and increased intestinal permeability have been recently pointed out as mechanisms involved in the etiology of these diseases, and in this context, IALP may assume a special relevance not only as a biomarker but also as a preventive and therapeutic strategy

Combined with regular cryotherapy for recovery optimization, this proactive strategy may reduce injury incidence over training careers

(e) Yi W, Cao RH, Chen ZY, et al

Eng 1 , 902913 (2017)