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doi: 10.1016/j.ejogrb.2014.06.008
Sarcoplasmic reticulum Ca 2+ release and uptake Sarcoplasmic reticulum (SR) Ca 2+ release and uptake mechanisms facilitate the majority of systolic intracellular Ca 2+ increases and diastolic decreases in the mammalian myocardium, respectively ( 2+ release channel is the cardiac ryanodine receptor (RyR2), while Ca 2+ is re-sequestered by the action of the SR Ca 2+ -ATPase (SERCA2a) ( Recent work by 2+ leak, resulting in reductions in the SR Ca 2+ content and cytosolic Ca 2+ transients
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In brown adipose tissue of mice, mitochondrial biogenesis and UCP1 expression was shown to increase with a ketone ester diet (110)
NMN is associated with a host of beneficial health effects in animal studies, including improved glucose and mitochondrial metabolism [48]
