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No human study has tested these combinations

Potential Side Effects While generally well tolerated, Tesofensine can cause: Dry mouth Insomnia (avoid late-day dosing) Increased heart rate or blood pressure Mild headache or restlessness These are typically dose-dependent and often resolve with continued use or dose adjustment

Gastrointestinal discomfort, changes in eating patterns, and metabolic shifts can all interfere with sleep quality

The glycine dose does not titrate upward with the tirzepatide component
