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Figure 1 3 Mitochondrial dysfunction is strongly associated with impaired glucose and lipid metabolism in obesity and diabetes Prolonged overload by nutrient substrates causes mitochondrial dysfunction (49), which can occur in multiple ways, including mitochondrial swelling, smaller mitochondrial cristae, imbalanced mitochondrial dynamics, and abnormalities in the mitochondrial respiratory chain (50, 51)

Treatment with P110, a selective inhibitor for FIS1-mediated DRP1 recruitment to the mitochondria, enhanced mitochondrial structure [135]

P = .048), physical strength (29% vs

Stimulant and Anticataplectic Effects of Reboxetine in Patients with Narcolepsy: A Pilot Study. Sleep , vol

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