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For example, the protein products of the CISD1 and CISD2 genes, MitoNEET and NAF-1, respectively, act together to transport ISCs into mitochondria

While the historical study of dietary antioxidants bears cautionary lessons (51) , in support of a critical antioxidant role for ergothioneine in vivo , the genetic knockout of SLC22A4 in Caenorhabditis elegans increased oxidative damage and reduced lifespan (52)

In mammals TRPA1 has both a central and a peripheral expression: # Central expression: The location of TRPA1 and TRPV1 on small diameter A and C fibres of sensory nerves is linked with its role in pain and inflammation

The importance of mitochondrial glutathione extends to neurological health, as neurons are particularly vulnerable to oxidative damage due to their high metabolic demand and limited regenerative capacity