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Animal studies show minimal toxicity at therapeutic doses over 11 days, with no observed hepatotoxicity, nephrotoxicity, or CNS effects

Both models showed increased sensitivity to known nephrotoxic drugs when compared to 2D cultures (Desrochers et al

In a 6-month, randomized, double-masked, placebo-controlled study, ruboxistaurin enhanced skin microvascular blood flow at the distal calf, reduced sensory symptoms, improved the quality of life, and was well tolerated in DPN patients

D.YongV

Notably, reactive astrocytes aberrantly produce GABA from putrescine via MAO-B, releasing it through the BEST1 channel 58,59