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Other factors Beyond the VEGF/VEGFR , EGF/EGFR , and PDGF/PDGFR axes, many other growth factors play indispensable roles in angiogenesis, such as fibroblast growth factor ( FGF ) /FGFR4 , hepatocyte growth factor ( HGF ) /c-Met , insulin-like growth factor ( IGF ) /IGFR , and transforming growth factor ( TGF- ) ( Figure 1 )

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Nanoparticle Cellular Uptake and Trafficking Lipid-based nanoparticles such as liposomes, solid lipid nanoparticles, nanostructured lipid carriers, and elastic vesicles can be taken up by cells through several mechanisms, including clathrin mediated endocytosis, caveolae mediated endocytosis, or macropinocytosis