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1 In this review, we focus on the secondary injury effects of mild TBI, and the various effective supplement and alternative strategies being investigated in both pre-clinical and clinical studies

39 FlochP.PeyV.CastroviejoM.DupuyJ.BonneuM.de la GuardiaA.et al (2014)

These findings advocate for the hypothesis that calcium homeostasis in the brain, particularly under hypoxic conditions, is modulated by lactylation modifications, which in turn, have a substantial impact on the pathological mechanisms of CIRI

Glycolysis Neoplastic tissues are characterized by acidosis due to high lactate levels produced by glycolysis (Warburg effect) and elevated glutamate concentrations stemming from glutamine metabolism

By influencing these metabolic and appetite-regulating pathways, these medications help individuals lose weight more effectively