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Kintscher, U., Foryst-Ludwig, A., Haemmerle, G

Mechanistic summaries on this page are provided for laboratory reference and should be interpreted within controlled experimental settings only. In diet-induced obese (DIO) mice, treatment with 5-Amino-1MQ at 20 mg/kg/day for 11 days via subcutaneous injection reduced body weight by approximately 5.1%, epididymal fat pad mass by 35%, adipocyte size by more than 30%, and plasma cholesterol by 30%, with no changes in food intake or observable adverse effects (Neelakantan et al., 2017)

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PEAK CONCN IN THE FETUSES WAS REACHED 24 HR AFTER DOSING, & FETAL ACCUMULATION WAS DOSE-DEPENDENT