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doi: 10.1177/2192568220981988

While LOX appears to be impacted by hypoxia, the specific cellular pathways are poorly understood, particularly in tendon

"Now that we know how it worked, that's a stepping stone to potentially using it for practical applications," Kadonaga said

Similarly to colchicine, podophyllotoxin binds the colchicine site at the interface of - and -tubulin, inhibits the assembly of tubulin into microtubules, blocks the cell cycle in G2/M phase, and finally leads to mitosis arrest 57,58

IAP, Inhibitors of Apoptosis
