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Upon stimulation, Nrf2 is translocated into the nucleus after dissociation from Keap1 (Itoh et al., 1999)
doi: 10.1038/70963
The future direction of andrographolide research is also introduced, as is the recent research that indicates its potential clinical application as an anti-inflammatory agent
Diagnosis is typically confirmed using the ankle-brachial index , with a ratio of less than 0.9 indicating significant disease
