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Butyrate is the main energy source for colonocytes and it performs several important functions such as maintaining the integrity of the intestinal epithelial barrier, regulating mucosal immune homeostasis, suppressing colonic NF-B-driven inflammation, inducing histone deacetylase inhibition, histone acetylation, gene expression changes, epigenetic gene regulation, and promoting apoptosis in pre-neoplastic colonocytes (50)

DNA repair : Glutathione is important for DNA repair

Cagrilintide is not FDA-approved as a standalone therapeutic

The multidrug resistance protein 1 participates in both the export of GSH and GSSG from astrocytes

Of the 17 exposed cases 15 had mutations and among the 21 unexposed cases 2 were found to have mutations (OR = 71.3)