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Interestingly, enhanced protein stability at low pH as a strategy to avoid acid induced unfolding has also been observed in many proteins including cytokines, interleukin-2 (IL-2) and granulocyte colony stimulating factor (G-CSF), which usually get internalised in acidic endosomal compartments, and capsid proteins which ensure viruss survival in acidic intestinal tract 18,19,20

It is used for peripheral neuropathy (pain in nerves, usually in lower limbs and hands)

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These insights provide a mechanistic foundation and strategic framework for the development of LAG-3/PD-1 bispecific antibodies and rational combination immunotherapies

[DOI] [PMC free article] [PubMed] [Google Scholar] 102.Gou LY, Li AN, Yang JJ, Zhang XC, Su J, Yan HH, Xie Z, Lou NN, Liu SY, Dong ZY, Gao HF, Zhou Q, Zhong WZ, Xu CR, Wu YL