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Therefore, simultaneous targeting of immunosuppressive agents, such as IDO and immune checkpoints (including PD-1 and CTLA-4), improves anti-tumor response [186, 196, 198, 200]

For patients diagnosed with a vitamin B12 deficiencyespecially when caused by problems with absorption in the digestive tract (such as pernicious anemia, certain gastrointestinal conditions, or after specific surgeries)oral supplements may not be effective

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(158) demonstrated that colonization of germ-free (GF) mice with a cocktail of 46 Clostridium (primarily belonging to clusters IV and XIVa ) robustly increases Foxp3+ Treg numbers in the colonic lamina propria (LP) without affecting small intestinal Tregs

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