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CD4 + T cell death was related to abnormal DNA and telomere damage and the emergence of diverse cell death pathways were associated with the expression of pro-/anti-apoptosis proteins and signaling molecules ( Cellular membranes have a role in defending against infection and maintaining the homeostasis of host cells

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As the primary factors for the reduced anticancer effect 1) the reduced delivery and uptake of the anticancer agent, 2) the need for the conversion of molecular oxygen (O 2 ) into reactive oxygen species (ROS), 3) the preferred therapeutic effect against highly proliferating cells, which is reduced under hypoxic conditions, or 4) adaptation of the cancer cells by promoting cell survival and upregulating certain resistance pathways, has been suggested 1,2,3,4,5

In the end, this aids in managing symptoms associated with PD [19]

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