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Cell Stem Cell 14 , 673688 (2014)

Targeting inflammation with collagen

Multiple interconnected factors drive this dysfunction: continuing adipocyte hypertrophy, worsening tissue hypoxia, and elevated circulating FFAs create self-reinforcing inflammatory cycles

Approximately 2% of the oxygen consumed by the mitochondria is converted into superoxide, making it one of the largest sources of endogenous ROS ( via -oxidation of fatty acid and flavin oxidase reaction and degrading ROS via catalase-mediated breakdown of H 2 O 2 ( Table 1 Formation of major oxidants
