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Additionally, the differential binding affinity between D1467G and wt was calculated for all peaks detected in wt and D1467G by performing another Fishers exact test comparing the read coverages in IP between both conditions, similar to the enrichment analysis between IP and SMI, but without considering an additional log2 fold change threshold

Aliment Pharmacol Ther 2019;49:10521059

doi: 10.1021/ac070023x

Talenezhad N, Mohammadi M, Ramezani-Jolfaie N, Mozaffari-Khosravi H, Salehi-Abargouei A

Based on this current clinical evidence, long term usage of LC should be strict avoided and one must not exceed the daily allowance to avoid the short term side effects as well as the risk of long term complications due to prolonged elevated TMAO levels