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As defined by the DSM5, an AUD is a problematic pattern of alcohol use leading to clinically significant impairment or distress (American Psychiatric Association, 2013).The estimated point prevalence of AUDs worldwide in 2016 in people aged 15 and over was 5.1% (over 283 million people

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[DOI] [PubMed] [Google Scholar] 119.Diekman E.F., de Koning T.J., Verhoeven-Duif N.M., Rovers M.M., van Hasselt P.M

J.PengW.et al

Its research value comes from observing changes across multiple readouts, including focal adhesion-associated signaling, paxillin-related adhesion remodeling, VEGFR2-axis endothelial responses, NO-related signaling, and tube-formation parameters