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This suggests that PKC is able to phosphorylate MOR at T370 and promotes its internalization

The gut microbiota modulates host homeostasis and physiological processes primarily through microbe-derived metabolites, which regulate systemic inflammation and neuronal function

(151) tested the anti-epileptic effects of dietary restriction regimens using epilepsy trials and found that the effects of IF varied with the epilepsy trial: IF increased epilepsy activity in the 6 Hz test and the maximal electroshock seizure test, provided no protective effect against pentylenetetrazol-induced epilepsy, but provided protection against kainic acid-induced epilepsy

Some mild breakouts may occur a sign of detoxification

Ohdate, T., Kita, K., Inoue, Y