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These multiple functionalities have contributed to the recent efforts to target GSTs with novel small molecule therapeutics

S-acetylglutathione has been shown to cross the membrane of the mitochondria, increasing the organelle's activity and minimizing ROS [Research 5, 6]

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Targeted metabolomics analysis revealed that GGCT knockdown significantly reduced the abundance of TCA cycle intermediates, while GGCT overexpression substantially increased their levels

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